Cordyceps Militaris Extract

1. Introduction:

Cordyceps militaris (C. militaris) is a medicinal mushroom possessing a variety of biofunctionalities. It has several biologically important components such as polysaccharides and others. The diverse pharmacological potential of C. militaris has generated interest in reviewing the current scientific literature, with a particular focus on prevention and associated molecular mechanisms in inflammatory diseases. Due to rising global demand, research on C. militaris has continued to increase in recent years. C. militaris  has shown the potential for inhibiting inflammation-related events, both in in vivo and in vitro experiments. Inflammation is a multifaceted biological process that contributes to the development and severity of diseases, including cancer, colitis, and allergies. These functions make C. militaris a suitable functional food for inhibiting inflammatory responses such as the regulation of proinflammatory cytokines. Therefore, on the basis of existing information, the current study provides insights towards the understanding of anti-inflammatory activity-related mechanisms.

Medicinal mushrooms have remained an important component of human culture. The genus Cordyceps is one of the largest genera in the family Clavicipitaceae. C. militaris is the second most popular, investigated species in its genus. Several pharmacological activities of this species have been documented, including blood glucose control, hypolipidemic, anti-tumor, anti-microbial, anti-viral, antiprotozoal, anti-inflammatory, neuroprotective, anti-oxidant and immuno-protective activities. Therefore, the C. militaris may be considered an important candidate for the treatment of different ailments.

Cordyceps Militaris have rich Chemical Constituents, Proteins and Peptides, Polysaccharides, Nucleosides; polyphenols and flavonoids; Mannitol and trehalose; carotenes and so on.

2. Specification offered by Hunan Huakang:

Botanical Source: Cordyceps Militaris     

Part Used: Fruit body/Mycelium    

Specification: Ratio Extract 4:1,10:1;

10%-50% Polysaccharides;

7%-40% Cordycepic Acid,3% Cordycepin;

30%-50% BETA D-Glucan.  

Active Ingredient: Polysaccharides/Cordycepic Acid/Cordycepin/BETA D-Glucan. 

3. Main Function:

1. Enhance human immunity;  

2. Regulate blood pressure;  

3. Increase energy level and reduces fatigue;  

4. With the function of antineoplastic, anti-aging, antibacterial and antiviral;  

5. Improve renal function and reduce the damage that toxic substances caused to the kidney.

The medicinal mushroom C. militaris has been widely consumed in China for medication purpose since ancient times (3000 years). It is used for therapeutic treatment of lung and kidney malfunction, hyperglycemia and hyperlipidemia, respiratory disorders, fatigue, treatment of night sweating, fertility issues, cardiac arrhythmias, and other heart diseases. On a broader scale, C. militaris has an array of pharmacological properties, including as inflammation inhibition, and antioxidant, antitumor, antimetastatic, immunomodulatory, hypoglycemic, and steroidogenic activities. Various pharmacological activities are presented in bellow.

4. Application Field:

1. Health care product

2. Pharmaceutics

Medicinal fungi are classical examples of natural riches pharmacological importance. In the pharmaceutical sector, C. militaris-associated bioactive ingredients may result in the development of a viable base for pharmaceutical industries for treatment and management of emerging diseases. In this regard, the species needs to be investigated by contemporary scientific methods including gene sequencing, precise analysis of bioactive chemicals and their screening, as well as pharmacological research and clinical trials. The food industry is already generating formulations with C. militaris constituents but two important parameters that require extensive work are the development of a complete safety profile, bioavailability studies and standardization of the pharmacodynamics parameters, as well as consideration of regulatory aspects.