Coptis Extract

Coptis Extract

Name: Coptis Extract

Latin Name: Coptis Chinensis Franch

Specification:  1%-98.0% Berberine hydrochloride Test by HPLC

Efficacy: Anti-Bacteria

1. Sources and Habitation

Coptis chinensis extract is rich in berberine, which is an alkaloid derived from Chinese goldthread, bark of cork tree and other plants. It can be also synthesized in artificial method. It is used as raw material to make preparations, which are usually administered the treatment of intestinal infections and bacillary dysentery. Recently usage of anti-arrhythmic was found.

2.Descriptions and Specifications of Product
Plant original: Berberis vulgaris

Specifications: 1%-98.0% Berberine hydrochloride Test by HPLC

Molecular Formula: C₂₀H₁₈ClNO₄·2H₂O

Molecular Mass: 407.85

CAS No: 633-65-8

Constitutional Formula:

3. Indications and Uses

As a traditional medicine or dietary supplement, berberine has showed some activity against fungal infections, Candida albicans, yeast, parasites, and bacterial/viral infections.Berberine seems to exert synergistic effects with fluconazole even in drug-resistant Candida albicans infections. Some research has  been undertaken into  possible use against MRSA infection; Berberine is considered an ineffective antibiotic.However, when applied in vitro and in combination with methoxyhydnocarpin, an inhibitor of multidrug resistance pumps, berberine inhibits growth of Staphylococcus aureus; Berberine is a component of some eye drop formulations. There is some evidence that it is useful in the treatment of trachoma,and it has been a standard treatment for leishmaniasis.Berberine prevents and supresses proinflammatory cytokines, E-selectin, and genes,  and increases adiponectin expression  which partly explains its versatile health effects. Berberine is a nucleic acid-binding isoquinolone  alkaloid with wide potential therapeutic properties.

4. Safety Concerns

Adverse reaction for oral administration is less nausea, vomiting, rash, fever, disappeared after drug withdrawal.

5. Dosage Information

Berberine was administered orally for 3 days or 1 week at a dosage of 7.5 or 15 mg/kg/day.

Tissue damage scores, body weight, colon wet weight, and colon wall thickness were measured, and myeloperoxidase activity in colon tissue was also examined. Histological lesions, morphological damage, and myeloperoxidase activity were reduced after 1 week of treatment with berberine at a dosage of 15 mg/kg/day.